This Month in Psychopharmacology

FDA Approves Tirzepatide for Adults with Obstructive Sleep Apnea and Obesity

The U.S. Food and Drug Administration (FDA) has approved tirzepatide (Zepbound®) for adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity. Tirzepatide may help adults with moderate-to-severe obstructive sleep apnea and obesity improve their sleep disorder. It should be used with a reduced-calorie diet and increased physical activity.


The approval was based on SURMOUNT-OSA phase 3 clinical trials, which were a multi-center, randomized, double-blind, parallel, placebo-master protocol comparing the efficacy and safety of tirzepatide (10 mg or 15 mg) to placebo in adults living with moderate-to-severe obstructive sleep apnea (OSA). Study 1 consisted of adults living with moderate-to-severe OSA and obesity who were unable or unwilling to use positive airway pressure (PAP) therapy, while Study 2 included adults living with moderate-to-severe OSA and obesity and planned to stay on PAP therapy during the duration of the trial. The trials randomized 469 participants across the U.S., Australia, Brazil, China, Czechia, Germany, Japan, Mexico and Taiwan in a 1:1 ratio to receive tirzepatide maximum tolerated dose of 10 mg or 15 mg or placebo. The primary objective of both studies was to demonstrate that tirzepatide is superior in change in apnea-hypopnea index (AHI) from baseline at 52 weeks as compared to placebo.


Tirzepatide was about five times more effective than placebo in reducing breathing disruptions in adults not on PAP therapy, leading to 25 fewer breathing disruptions per hour with tirzepatide and five with placebo. In adults on PAP therapy, tirzepatide led to 29 fewer breathing disruptions per hour compared to six with placebo. After one year, 42% of adults on tirzepatide and 50% of adults on tirzepatide with PAP therapy experienced remission or mild, non-symptomatic OSA, compared to 16% and 14% on placebo, respectively.


In addition to improved OSA symptoms, adults on tirzepatide lost an average of 45 lbs (18%) of their body weight, while adults on tirzepatide with PAP therapy lost an average of 50 lbs (20%) of their body weight, compared to 4 lbs (2%) and 6 lbs (2%) on placebo, respectively. Tirzepatide is the first and only prescription medicine FDA-approved for moderate-to-severe obstructive sleep apnea in adults with obesity.


Mechanism of Action


  • Glucagon-like peptide-1 (GLP-1) receptor agonist
  • Glucose-dependent insulinotropic polypeptide (GIP) receptor agonist
  • Selectively binds to and activates both GLP-1 GIP receptors in the CNS and periphery
  • Lowers blood glucose by stimulating insulin release, increasing insulin sensitivity and lowering glucagon secretion in the presence of elevated blood glucose concentrations
  • Also delays gastric emptying and slows post-meal glucose absorption, reducing postprandial glucose
  • Activation of central GLP-1 receptors in areas involved in hunger/satiety (e.g., the hypothalamus) decreases appetite and increases the sense of fullness

>> Eli Lilly and Company Press Release


Additional Education and Resources

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Encore Presentation
No Rest for the Weary: An Update on the Diagnosis and Treatment of Hypersomnia Disorders
CME/CE Credit: 0.75 | Expires: November 12, 2026

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CME/CE Article
Weighing the Effects of GLP-1 Receptor Agonists in Serious Mental Illness
CME/CE Credit: 1.0   |  Expires: May 13, 2027

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NEI Psychopharm YouTube Channel
What's Gut? (GLP-1)

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Mechanism of Action
Neurocircuitry of Sleep and Wakefulness
CME/CE Credit: 0.25  |  Expires: March 14, 2026

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Encore Presentation
Don't Fall Asleep: Screening, Diagnosis, and Management of Narcolepsy and Idiopathic Hypersomnia
CME/CE Credit: 0.50  |  Expires: November 6, 2025

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Patient Education
Patient Diaries: Sleep Diary
Patient handouts!

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Stahl's Essential Videos
Stahl’s Essential Psychopharmacology, Chapter 10b: Diagnosis and Treatment of Sleep/Wake Disorders
CME/CE credits: 0.75  |  Expires: March 10, 2025

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