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Glutamate Neurotransmission
Mechanism of Action (MOA) animations offer a clear, concise, and easy-to-follow format designed to better enable participants to understand the intricacies of how the brain works and how drugs act in the brain. Audio guides synched to the animation further ensure that participants can follow along with ease and at their pace. This animation depicts the process of glutamate neurotransmission, which is critical to learning and memory processes such as long-term potentiation and synaptic plasticity.
[ Stephen M. Stahl, MD, PhD ]
MPP: Mechanisms of Action added 08/31/2010. CME credit is not available

The prefrontal cortex: a target for antipsychotic drugs
Articles are an integral part of the education system of practicing clinicians. By keeping up-to-date on medical literature, practitioners may be better prepared to handle difficult cases that present to their practice. Furthermore, articles offer an opportunity for practitioners to brush up on background information, as well as providing new information on up-and-coming research and treatments in the field of psychopharmacology. This article briefly reviews the mechanism of action of antipsychotics in the prefrontal cortex.
MPP: Articles added 07/13/2010. CME credit is not available

Psychosis and Schizophrenia, Expert Clinical Case 4—The Case: 45-Year-Old With Partial Response and Side Effects, Part 2
NEI’s Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is an Expert Clinical Case—a real patient case pulled from the files of NEI’s distinguished faculty. Participants are able to review the case, answer questions regarding potential management options, view peer responses, and learn what actually happened in the case. This particular Expert Clinical Case explores the management options for a patient with bipolar disorder and metabolic side effects from an atypical antipsychotic.
Online Digest: Expert Clinical Case added 06/28/2010. Complete all activities in this Online Digest for CME credit

Psychosis and Schizophrenia, Concept in Motion 4: Switching Strategies for Antipsychotics
NEI's Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is a Concept in Motion—an animated or audiovisual explanation of a difficult concept. Audio is synched to the animation or visual presentation to further ensure that participants can follow along with ease. In this Concept in Motion, Dr. Stephen Stahl demonstrates the postulated dysregulation of glutamate in schizophrenia and the potential therapeutic use of glutamate receptor agonists.
Online Digest: Concept in Motion added 06/21/2010. Complete all activities in this Online Digest for CME credit

Psychosis and Schizophrenia, Research Highlights 4: Maximizing Adherence and Patient Outcomes
NEI's Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is Research Highlights—a concise review of the latest research and clinical findings on a particular topic. The brief overview article provides an easy way for clinicians to stay up-to-date on clinically relevant research. This Research Highlights discusses recent research on improving functional outcomes in schizophrenic patients, including maximizing medication adherence.
Online Digest: Research Highlight added 06/14/2010. Complete all activities in this Online Digest for CME credit

Antipsychotic Actions at Serotonin Receptors
Mechanism of Action (MOA) animations offer a clear, concise, and easy-to-follow format designed to better enable participants to understand the intricacies of how the brain works and how drugs act in the brain. Audio guides synched to the animation further ensure that participants can follow along with ease and at their pace. This animation depicts the effects of antipsychotic actions at serotonin 1A and 2C receptors.
[ Stephen M. Stahl, MD, PhD ]
MPP: Mechanisms of Action added 06/08/2010. CME credit is not available

Psychosis and Schizophrenia, Concept in Motion 3: Cortical Glutamate Regulation
NEI's Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is a Concept in Motion—an animated or audiovisual explanation of a difficult concept. Audio is synched to the animation or visual presentation to further ensure that participants can follow along with ease. In this Concept in Motion, Dr. Stephen Stahl demonstrates the postulated dysregulation of glutamate in schizophrenia and the potential therapeutic use of glutamate receptor agonists.
[ Stephen M. Stahl, MD, PhD ]
Online Digest: Concept in Motion added 05/31/2010. Complete all activities in this Online Digest for CME credit

Psychosis and Schizophrenia, Research Highlights 3: New and Emerging Antipsychotics--Targeting Receptors with Intramolecular Polypharmacy
NEI’s Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is Research Highlights—a concise review of the latest research and clinical findings on a particular topic. The brief overview article provides an easy way for clinicians to stay up-to-date on clinically relevant research. This Research Highlights discusses recently approved antipsychotics and antipsychotics with approval pending, as well as novel mechanisms of antipsychotic action that are currently under investigation.
Online Digest: Research Highlight added 05/24/2010. Complete all activities in this Online Digest for CME credit

From Clinical Trials to Clinical Practice: Recent Developments in Antipsychotic Therapy
In this archived webinar, Drs. Andrew Cutler and Stephen Stahl discuss the mechanistic and clinical profiles of recently approved antipsychotics as well as of those in late-stage and earlier clinical development. The original live broadcast of the webinar consisted of a 45-minute interview-style discussion followed by a 20-minute live question and answer period hosted by one of the faculty. There is no CME credit available for this archived version.
[ Andrew J Cutler MD - Stephen M. Stahl, MD, PhD ]
Webinar Archive added 05/20/2010. CME credit is not available

Psychosis and Schizophrenia, Expert Clinical Case 2--The Case: 45-Year-Old with Partial Response and Side Effects, Part 1
NEI’s Online Digest is a unique educational model that provides participants the opportunity to learn the essentials of psychopharmacology through a series of short, easily-digested, and interactive components. One such component is an Expert Clinical Case—a real patient case pulled from the files of NEI’s distinguished faculty. Participants are able to review the case, answer questions regarding potential management options, view peer responses, and learn what actually happened in the case. This provides a practical and clinically relevant learning experience in which the participant plays an active role. This particular Expert Clinical Case explores the management options for a patient with partial response and side effects.
[ Stephen M. Stahl, MD, PhD ]
Online Digest: Expert Clinical Case added 05/17/2010. Complete all activities in this Online Digest for CME credit

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09 September 2010